منابع مشابه
Secreting Tumor Suppression
Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed ...
متن کاملRenin-secreting tumor. Case report.
Renin-secreting tumor, though rare, should be considered in assessing severe hyperreninemic, hypertensive patients. We studied an 18-year-old girl with hypokalemic hyperreninemic hyperaldosteronism. No angiographic lesion could be detected. The plasma renin activity (PRA) of the right/left renal vein was 7.3. With a presumptive diagnosis of renin-secreting tumor (RST), the patient was operated ...
متن کاملTumor suppression
The tumor suppressor gene TP53 and its gene product—a veritable swiss Army knife of cellular regulation—have been the targets of intense study since their discovery in 1979. 1-3 indeed, a PubMed search for the term " p53 " retrieves more than 68 000 citations, and more than 100 physical or genetic interactions with TP53 have been identified to date. its importance in cancer biology was recogniz...
متن کاملCase Reports Renin-Secreting Tumor Case Report
Renin-secreting tumor, though rare, should be considered in assessing severe hyperreninemic, hypertensive patients. We studied an 18-year-old girl with hypokalemic hyperreninemic hyperaldosteronism. No angiographic lesion could be detected. The plasma renin activity (PRA) of the right/left renal vein was 7 3 . With a presumptive diagnosis of renin-secreting tumor (RST), the patient was operated...
متن کاملAn adrenocortical tumor secreting weak mineralocorticoids.
An adrenocortical carcinoma (15.5 g) secreting excessive amounts of steroids with weak mineralocorticoid activity in a 25-year-old woman was studied with particular reference to its in vivo and in vitro secretions of steroids. Severe hypertension, occasional low serum potassium and suppressed PRA were the major clinical findings, and were improved with removal of the tumor. In the preoperative ...
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ژورنال
عنوان ژورنال: Cell
سال: 2008
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.01.022